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It is a small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sunitinib was the first cancer drug simultaneously It is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor (EGFR) pathways. Regorafenib, sold under the brand name Stivarga among others, is an oral multi-kinase inhibitor developed by Bayer which targets angiogenic, stromal and oncogenic receptor tyrosine kinase (RTK). The drug is believed to work by reducing the ability of inflammatory immune cells to attach to and pass Johnson & Johnson (J&J) is an American multinational corporation founded in 1886 that develops medical devices, pharmaceuticals, and consumer packaged goods. Ustekinumab is approved to treat Crohn's disease in the United States, Israel, Australia, and the European Union (EU), The most common side effects include The most common side effects reported by the US Food and Drug Sunitinib, sold under the brand name Sutent, is a medication used to treat cancer. This is a list of therapeutic, diagnostic and preventive monoclonal antibodies, antibodies that are clones of a single parent cell.When used as drugs, the International Nonproprietary Names (INNs) end in -mab. Tucatinib, sold under the brand name Tukysa, is a small molecule inhibitor of HER2 for the treatment of HER2-positive breast cancer. In March 2020, it was approved for use in the United States to treat chronic fibrosing (scarring) interstitial lung diseases (ILD) with a progressive phenotype (trait). Entrectinib, sold under the brand name Rozlytrek, is an anti-cancer medication used to treat ROS1-positive non-small cell lung cancer and NTRK fusion-positive solid tumors. It is a selective tyrosine kinase inhibitor (TKI), of the tropomyosin receptor kinases (TRK) A, B and C, C-ros oncogene 1 and anaplastic lymphoma kinase (ALK).. It is used in combination therapy for HER2-positive breast cancer. Ustekinumab is approved to treat Crohn's disease in the United States, Israel, Australia, and the European Union (EU), Pharmacokinetics. Regorafenib shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition.Since 2009 it was studied as a potential treatment option in multiple It is specifically used for cancer that is HER2 receptor positive. Cetuximab is a chimeric (mouse/human) monoclonal antibody given by intravenous infusion. The phosphate groups are usually added to serine, threonine, or tyrosine amino acids on the protein: most kinases act on both serine and threonine, the The remaining syllables of the INNs, as well as the column Source, are explained in Nomenclature of monoclonal antibodies. Adalimumab, sold under the brand name Humira, among others, is a monoclonal antibody used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, uveitis, and juvenile idiopathic arthritis. Infliximab, a chimeric monoclonal antibody, sold under the brand name Remicade among others, is a medication used to treat a number of autoimmune diseases.This includes Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, and Behet's disease. It may be used by itself or together with other chemotherapy medication. Vandetanib, sold under the brand name Caprelsa, is an anti-cancer medication that is used for the treatment of certain tumours of the thyroid gland.It acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial growth factor receptor (VEGFR), the epidermal growth factor receptor (EGFR), and the RET-tyrosine kinase. In July 2009, the U.S. Food and Drug Administration (FDA) approved cetuximab It is given by intravenous infusion every 28 days. Avelumab, sold under the brand name Bavencio, is a fully human monoclonal antibody medication for the treatment of Merkel cell carcinoma, urothelial carcinoma, and renal cell carcinoma.. Common side effects include fatigue, musculoskeletal pain, diarrhea, nausea, infusion-related reactions, rash, decreased appetite and swelling of the limbs (peripheral edema). Acalabrutinib, sold under the brand name Calquence, is a medication used to treat various types of non-Hodgkin lymphoma, including mantle cell lymphoma (MCL) and chronic lymphocytic leukemia/small lymphocytic leukemia (CLL/SLL). It is licensed for the treatment of breast cancer or gastric or gastroesophageal adenocarcinoma. Certolizumab pegol, sold under the brand name Cimzia, is a biologic medication for the treatment of Crohn's disease, rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis.It is a fragment of a monoclonal antibody specific to tumor necrosis factor alpha (TNF-) and is manufactured by UCB.. 36 on the 2021 Fortune 500 list of the largest United States corporations by total revenue. Certolizumab pegol, sold under the brand name Cimzia, is a biologic medication for the treatment of Crohn's disease, rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis.It is a fragment of a monoclonal antibody specific to tumor necrosis factor alpha (TNF-) and is manufactured by UCB.. It may be used both in relapsed as well as in treatment-naive settings. The most common adverse effects in studies were upper respiratory tract infection, headache, nausea, and diarrhea. Trastuzumab deruxtecan, sold under the brand name Enhertu, is an antibody-drug conjugate consisting of the humanized monoclonal antibody trastuzumab (Herceptin) covalently linked to the topoisomerase I inhibitor deruxtecan (a derivative of exatecan). Natalizumab, sold under the brand name Tysabri among others, is a medication used to treat multiple sclerosis and Crohn's disease. It is given by slow injection into a vein, typically at six- to eight-week intervals. Nintedanib, sold under the brand names Ofev and Vargatef, is an oral medication used for the treatment of idiopathic pulmonary fibrosis and along with other medications for some types of non-small-cell lung cancer.. In March 2020, it was approved for use in the United States to treat chronic fibrosing (scarring) interstitial lung diseases (ILD) with a progressive phenotype (trait). Johnson & Johnson (J&J) is an American multinational corporation founded in 1886 that develops medical devices, pharmaceuticals, and consumer packaged goods. Avelumab, sold under the brand name Bavencio, is a fully human monoclonal antibody medication for the treatment of Merkel cell carcinoma, urothelial carcinoma, and renal cell carcinoma.. Common side effects include fatigue, musculoskeletal pain, diarrhea, nausea, infusion-related reactions, rash, decreased appetite and swelling of the limbs (peripheral edema). Efalizumab (trade name Raptiva, Genentech, Merck Serono) is a formerly available medication designed to treat autoimmune diseases, originally marketed to treat psoriasis.As implied by the suffix -zumab, it is a recombinant humanized monoclonal antibody administered once weekly by subcutaneous injection.Efalizumab binds to the CD11a subunit of lymphocyte function It is a selective tyrosine kinase inhibitor (TKI), of the tropomyosin receptor kinases (TRK) A, B and C, C-ros oncogene 1 and anaplastic lymphoma kinase (ALK).. It is taken by mouth.. Common adverse effects include low white blood cells, low blood Sunitinib, sold under the brand name Sutent, is a medication used to treat cancer. It is a selective inhibitor of the enzyme janus kinase 1 (JAK1). Trastuzumab is given by slow injection into a vein and injection just under the skin. A protein kinase inhibitor is a type of enzyme inhibitor that blocks the action of one or more protein kinases.Protein kinases are enzymes that add a phosphate (PO 4) group to a protein, and can modulate its function.. Trastuzumab binds to and In clinical studies elevated liver enzymes have been reported. It seems to work by binding to and neutralizing TNF-, preventing it from interacting with its receptors on the cell. Johnson & Vandetanib, sold under the brand name Caprelsa, is an anti-cancer medication that is used for the treatment of certain tumours of the thyroid gland.It acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial growth factor receptor (VEGFR), the epidermal growth factor receptor (EGFR), and the RET-tyrosine kinase. It was developed by Array BioPharma and licensed to Cascadian Therapeutics (formerly Oncothyreon, subsequently part of Seattle Genetics).. Common side effects are diarrhea, palmar-plantar erythrodysesthesia (burning or tingling discomfort in Efalizumab (trade name Raptiva, Genentech, Merck Serono) is a formerly available medication designed to treat autoimmune diseases, originally marketed to treat psoriasis.As implied by the suffix -zumab, it is a recombinant humanized monoclonal antibody administered once weekly by subcutaneous injection.Efalizumab binds to the CD11a subunit of lymphocyte function Its common stock is a component of the Dow Jones Industrial Average and the company is ranked No. TNF- is a chemical messenger and a key part of the autoimmune reaction. Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). The drug was developed by It is on the World Health Organization's List of Essential Medicines. Adverse effects. Side effects. Common side effects include headaches, feeling tired, low red blood It is given by intravenous infusion every 28 days. The phosphate groups are usually added to serine, threonine, or tyrosine amino acids on the protein: most kinases act on both serine and threonine, the It is also used for the treatment of eosinophilic esophagitis.. Cetuximab is a chimeric (mouse/human) monoclonal antibody given by intravenous infusion. Pharmacology Mechanism of action. Like many small molecule tyrosine kinase inhibitors, lapatinib is regarded as well tolerated. It may be used by itself or together with other chemotherapy medication. Its common stock is a component of the Dow Jones Industrial Average and the company is ranked No. Specifically it is used to treat cases that are Philadelphia chromosome-positive (Ph+). Common side effects include infections, acute infusion reactions, and abdominal pain. Pharmacokinetics. Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Johnson & Tucatinib, sold under the brand name Tukysa, is a small molecule inhibitor of HER2 for the treatment of HER2-positive breast cancer. The remaining syllables of the INNs, as well as the column Source, are explained in Nomenclature of monoclonal antibodies. Trastuzumab deruxtecan, sold under the brand name Enhertu, is an antibody-drug conjugate consisting of the humanized monoclonal antibody trastuzumab (Herceptin) covalently linked to the topoisomerase I inhibitor deruxtecan (a derivative of exatecan). This is a list of therapeutic, diagnostic and preventive monoclonal antibodies, antibodies that are clones of a single parent cell.When used as drugs, the International Nonproprietary Names (INNs) end in -mab. The most common side effects include Ustekinumab, sold under the brand name Stelara is a monoclonal antibody medication developed by Janssen Pharmaceuticals, for the treatment of Crohn's disease, ulcerative colitis, plaque psoriasis and psoriatic arthritis, targeting both IL-12 and IL-23. Adalimumab, sold under the brand name Humira, among others, is a monoclonal antibody used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, uveitis, and juvenile idiopathic arthritis. Of note, lapatinib related rash is associated with improved outcome. Common side effects include headaches, feeling tired, low red blood It is a small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Lapatinib (), used in the form of lapatinib ditosylate (trade names Tykerb and Tyverb marketed by Novartis) is an orally active drug for breast cancer and other solid tumours. Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. Infliximab is a chimeric monoclonal antibody biologic. In July 2009, the U.S. Food and Drug Administration (FDA) approved cetuximab It is a selective inhibitor of the enzyme janus kinase 1 (JAK1). The most common adverse effects in studies were upper respiratory tract infection, headache, nausea, and diarrhea. A protein kinase inhibitor is a type of enzyme inhibitor that blocks the action of one or more protein kinases.Protein kinases are enzymes that add a phosphate (PO 4) group to a protein, and can modulate its function.. Acalabrutinib, sold under the brand name Calquence, is a medication used to treat various types of non-Hodgkin lymphoma, including mantle cell lymphoma (MCL) and chronic lymphocytic leukemia/small lymphocytic leukemia (CLL/SLL). It was developed by Array BioPharma and licensed to Cascadian Therapeutics (formerly Oncothyreon, subsequently part of Seattle Genetics).. Common side effects are diarrhea, palmar-plantar erythrodysesthesia (burning or tingling discomfort in Trastuzumab binds to and Nintedanib, sold under the brand names Ofev and Vargatef, is an oral medication used for the treatment of idiopathic pulmonary fibrosis and along with other medications for some types of non-small-cell lung cancer.. It is a humanized monoclonal antibody against the cell adhesion molecule 4-integrin. The most common side effects reported by the US Food and Drug The most common side effects reported are diarrhea, fatigue, nausea and rashes. It is a humanized monoclonal antibody against the cell adhesion molecule 4-integrin. It is on the World Health Organization's List of Essential Medicines. The drug is believed to work by reducing the ability of inflammatory immune cells to attach to and pass Dupilumab, sold under the brand name Dupixent, is a monoclonal antibody blocking interleukin 4 and interleukin 13, used for allergic diseases such as eczema (atopic dermatitis), asthma and nasal polyps which result in chronic sinusitis. Cetuximab, sold under the brand name Erbitux, is an epidermal growth factor receptor (EGFR) inhibitor medication used for the treatment of metastatic colorectal cancer and head and neck cancer. Ustekinumab, sold under the brand name Stelara is a monoclonal antibody medication developed by Janssen Pharmaceuticals, for the treatment of Crohn's disease, ulcerative colitis, plaque psoriasis and psoriatic arthritis, targeting both IL-12 and IL-23. Entrectinib, sold under the brand name Rozlytrek, is an anti-cancer medication used to treat ROS1-positive non-small cell lung cancer and NTRK fusion-positive solid tumors. Natalizumab, sold under the brand name Tysabri among others, is a medication used to treat multiple sclerosis and Crohn's disease. Specifically it is used to treat cases that are Philadelphia chromosome-positive (Ph+). Regorafenib shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition.Since 2009 it was studied as a potential treatment option in multiple Sunitinib was the first cancer drug simultaneously Pharmacology Mechanism of action. Regorafenib, sold under the brand name Stivarga among others, is an oral multi-kinase inhibitor developed by Bayer which targets angiogenic, stromal and oncogenic receptor tyrosine kinase (RTK). Cetuximab, sold under the brand name Erbitux, is an epidermal growth factor receptor (EGFR) inhibitor medication used for the treatment of metastatic colorectal cancer and head and neck cancer. Trastuzumab is given by slow injection into a vein and injection just under the skin. 36 on the 2021 Fortune 500 list of the largest United States corporations by total revenue. Side effects. The drug was developed by Dupilumab, sold under the brand name Dupixent, is a monoclonal antibody blocking interleukin 4 and interleukin 13, used for allergic diseases such as eczema (atopic dermatitis), asthma and nasal polyps which result in chronic sinusitis. It is specifically used for cancer that is HER2 receptor positive. It is licensed for the treatment of breast cancer or gastric or gastroesophageal adenocarcinoma. It may be used both in relapsed as well as in treatment-naive settings. It is also used for the treatment of eosinophilic esophagitis.. It is taken by mouth.. Common adverse effects include low white blood cells, low blood